1423381-07-0
中文名稱
Pep2m, myristoylated
英文名稱
Pep2m, myristoylated
CAS
1423381-07-0
分子式
C63H118N18O14S
分子量
1383.81
MOL 文件
1423381-07-0.mol
1423381-07-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.32±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
酸度系數(shù)(pKa)3.25±0.10(Predicted)
水溶解性Soluble to 1 mg/ml in sterile water
常見問題列表
生物活性
Pep2m, myristoylated (Myr-Pep2m) 是一種細(xì)胞通透性肽。Pep2m, myristoylated (Myr-Pep2m) 能破壞蛋白激酶 ζ (PKMζ) 下游靶點(diǎn) NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。靶點(diǎn)
NSF/GluR2 interactions
體外研究
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
體內(nèi)研究
Pep2m, myristoylated (10 μg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
| Animal Model: | Female and male Long-Evans hooded rats (8 weeks) |
| Dosage: | 10 μg (in 20 μL) |
| Administration: | Intrathecal injection |
| Result: | Resulted in an increase in PWTs, in both male and female rats at various time points tested. |