142523-38-4
中文名稱
L-690,330
英文名稱
L-690,330
CAS
142523-38-4
分子式
C8H12O8P2
分子量
298.12
MOL 文件
142523-38-4.mol
更新日期
2023/03/20 15:41:19
142523-38-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15685 英文別名
L-690,330[1-(4-HYDROXYPHENOXY)ETHYLIDENE]BISPHOSPHONIC ACID
Phosphonic acid, P,P'-[1-(4-hydroxyphenoxy)ethylidene]bis-
物理化學(xué)性質(zhì)
沸點696.9±65.0 °C(Predicted)
密度1.787±0.06 g/cm3(Predicted)
儲存條件Store at RT
溶解度Water:19.65(Max Conc. mg/mL);65.9(Max Conc. mM)
酸度系數(shù)(pKa)1.44±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
水溶解性Soluble to 20 mM in water
InChI1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15)
InChIKeyJKOCAAWWDVHWKB-UHFFFAOYSA-N
SMILESOC1=CC=C(OC(C)(P(O)(O)=O)P(O)(O)=O)C=C1
L-690,330價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-101075 | L-690,330 L-690330 | 142523-38-4 | 5mg | 1600元 |
| 2026/06/05 | HY-101075 | L-690,330 L-690330 | 142523-38-4 | 10 mM * 1 mL in Water | 1760元 |
| 2026/06/05 | HY-101075 | L-690330 | 142523-38-4 | 10 mg | 2600元 |
常見問題列表
生物活性
L-690330 是一種競爭性的肌醇單磷酸酶 (inositol monophosphatase (IMPase)) 抑制劑，對重組人和牛 IMPase 的 Ki 值為 0.27 μM 和 0.19 μM，對人和牛前腦皮層 IMPase 的為 Ki 值為 0.30 μM 和 0.42 μM。L-690330 對其敏感性是大鼠和小鼠的 IMPase 的 10 倍。靶點
Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)
體外研究
L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1 hour |
| Result: | Improved LC3-I/II and p-AMPK protein level. |
體內(nèi)研究
L-690330 (intracerebroventricular?injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test.
| Animal Model: | Eight-week-old male ICR mice |
| Dosage: | 0.1 μmol |
| Administration: | Intracerebroventricular?injection |
| Result: | Did not effect mice well-being by i.c.v injection. |