1426214-51-8
中文名稱
SGK1 Inhibitor
英文名稱
SGK1 Inhibitor
CAS
1426214-51-8
分子式
C17H12Cl2N6O2S
分子量
435.29
MOL 文件
1426214-51-8.mol
1426214-51-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 SGK1 INHIBITOR 英文別名
N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichloro-benzenesulfonamideBenzenesulfonamide, N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichloro-
物理化學(xué)性質(zhì)
沸點(diǎn)730.5±70.0 °C(Predicted)
密度1.660±0.06 g/cm3(Predicted)
溶解度DMSO: soluble
酸度系數(shù)(pKa)5.86±0.10(Predicted)
形態(tài)A solid
應(yīng)用領(lǐng)域
用途一
SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.