1428630-86-7
中文名稱(chēng)
ML 254
英文名稱(chēng)
ML 254
CAS
1428630-86-7
分子式
C18H15FN2O2
分子量
310.32
MOL 文件
1428630-86-7.mol
更新日期
2024/07/23 09:31:05
1428630-86-7 結(jié)構(gòu)式
基本信息
中文別名
5-((3-氟苯基)乙炔基)-N-(3-甲基氧雜-3-基)吡啶啉酰胺 英文別名
ML 2545-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide
5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyloxetan-3-yl)pyridine-2-carboxamide
2-Pyridinecarboxamide, 5-[2-(3-fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-
應(yīng)用領(lǐng)域
用途一
ML-254, also known as VU0430644; is Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents. Preliminary experiments at a single dose in an in vivo model of psychosis using ML254 demonstrates a robust reversal of amphetamine induced hyperlocomotion. ML254 will serve as a significant pure-PAM tool compound for the field with potential for studies within in vivo paradigms. Structure activity relationship (SAR) and characterization of ML254 are described.常見(jiàn)問(wèn)題列表
概述
ML254 是一種有效的 mGlu5 增強(qiáng)劑，對(duì)小鼠 mGlu5 的 EC50 和 pEC50 分別為 9.3 nM。ML254 可用于研究精神分裂癥。