1430420-02-2
1430420-02-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 HJC-0123 英文別名
HJC-01234-Quinolinecarboxamide, N-(1,1-dioxidobenzo[b]thien-6-yl)-2-phenyl-
應(yīng)用領(lǐng)域
用途一
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.