1433222-47-9
中文名稱(chēng)
KISS1R激動(dòng)劑
英文名稱(chēng)
TAK-448
CAS
1433222-47-9
分子式
C64H90F3N17O16
分子量
1410.52
MOL 文件
1433222-47-9.mol
1433222-47-9 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
TAK-448 is an investigational oligopeptide analog of kisspeptin and a potent agonist of the GPR54 receptor. In animals, acute TAK-448 administration stimulates LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. TAK-448 has exhibited potent antitumor activity in rat androgen-dependent prostate cancer models. Therefore, TAK-448 may be useful in the treatment of PC in humans..