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1435786-04-1

中文名稱 1435786-04-1
英文名稱 GLYX13
CAS 1435786-04-1
分子式 C20H32F3N5O8
分子量 527.5
MOL 文件 1435786-04-1.mol
1435786-04-1 結(jié)構(gòu)式 1435786-04-1 結(jié)構(gòu)式

基本信息

中文別名
化合物RAPASTINEL TRIFLUOROACETATE
英文別名
Rapastinel Trifluoroacetate

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 125 mg/mL (236.97 mM)
形態(tài)Solid
顏色White to off-white
1435786-04-1價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/12/22HY-16728B1435786-04-1
Rapastinel Trifluoroacetate
1435786-04-15mg950元
2025/12/22HY-16728B1435786-04-1
Rapastinel Trifluoroacetate
1435786-04-110 mM * 1 mLin DMSO1102元
2025/12/22HY-16728B1435786-04-1
Rapastinel Trifluoroacetate
1435786-04-110mg1500元

常見(jiàn)問(wèn)題列表

生物活性
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一種具有甘氨酸位點(diǎn)部分激動(dòng)劑性質(zhì)的 NMDA 受體調(diào)節(jié)劑。Rapastinel Trifluoroacetate 有潛力用于抑郁癥的研究
靶點(diǎn)

NMDA receptor

體內(nèi)研究

Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P<0.01). Rapastinel Trifluoroacetate produces an antidepressant like effect in the USVs test, as indexed by an increase in hedonic 50-kHz USVs [F(1,20)=12.4, P<0.05] and a decrease in aversive 20-kHz USVs [F(1,20)=6.8, P<0.05]. Rapastinel Trifluoroacetate also produces an anxiolytic effect in the open field, as indexed by increased center time [F(1,20)=19.2, P<0.05] without altering locomotor activity as measured by line crosses [F(1,20)=0.0, P>0.05].

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