143984-17-2
中文名稱
Y-29794 tosylate
英文名稱
Y-29794 tosylate
CAS
143984-17-2
分子式
C30H42N2O4S3
分子量
590.86
MOL 文件
143984-17-2.mol
143984-17-2 結(jié)構(gòu)式
基本信息
中文別名
化合物Y-29794 TOSYLATE 英文別名
Y-29794 tosylate(2-((8-(dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate
應用領(lǐng)域
用途一
Y-29794 Tosylate is an orally active, potent and specific non-peptide prolyl endopeptidase (PPCE) inhibitor. Y-29794 selectively and competitively inhibited rat brain PPCE (Ki = 0.95 nM) in a reversible manner. Ex vivo study demonstrated that Y-29794 could penetrate into brain to exhibit dose-dependent and long-lasting inhibition. Furthermore, Y-29794 could potentiate the effect of TRH on the release of ACh in the rat hippocampus. Y-29794 prevents the progression of A beta-like deposition in the hippocampus of the SAM.