144164-11-4
144164-11-4 結(jié)構(gòu)式
基本信息
利托那韋雜質(zhì)26
(2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧羰基)氨基)-1,6-二苯基-3-羥基己烷
(2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧基羰基)氨基)-1,6-二苯基-3-羥基己烷
RIT-X
RitovirImpurity20
Ritonavir Impurity 1
Ritonavir Impurity 26
Ritonavir Intermediate 2
amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
(5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamic acid
(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino...
Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-
物理化學(xué)性質(zhì)
制備方法
162849-95-8
144164-11-4
實(shí)施例4. (2S,3S,5S)-5-氨基-2-(N-((5-噻唑基)-甲氧基羰基)氨基)-1,6-二苯基-3-羥基己烷的制備: 將(2S,3S,5S)-5-(叔丁氧羰基氨基)-2-(N-5-噻唑基甲氧羰基)氨基-1,6-二苯基-3-羥基己烷 (1.2g, 6.2mmol) 溶于4N HCl/二惡烷溶液(12mL)中，室溫下攪拌反應(yīng)3小時(shí)。反應(yīng)完成后，將混合物在真空下濃縮，殘余物用EtOAc研磨，過(guò)濾后得到白色固體產(chǎn)物(0.93g, 產(chǎn)率98.2%)。產(chǎn)物經(jīng)1H NMR (300MHz, DMSO-D6) 表征: δ 1.58 (t, J = 6.3Hz, 2H), 2.54-2.68 (m, 1H), 2.72-2.93 (m, 3H), 3.41-3.55 (m, 1H), 5.13 (s, 2H), 7.04-7.47 (m, 11H), 7.84 (s, 1H), 9.07 (s, 1H); MS (ESI) m/z 426.1 (M + H)+。
參考文獻(xiàn)：
[1] Patent: WO2008/27932, 2008, A2. Location in patent: Page/Page column 96
[2] Patent: WO2006/90264, 2006, A1. Location in patent: Page/Page column 22-23
[3] Patent: WO2006/90270, 2006, A1. Location in patent: Page/Page column 11
[4] Patent: EP1170289, 2002, A2. Location in patent: Page 45
[5] Patent: WO2005/111006, 2005, A1. Location in patent: Page/Page column 17-18