14417-88-0
14417-88-0 結(jié)構(gòu)式
基本信息
化合物 T16036
CS-2397
Melinamide
DL-a-Methylbenzyl linoleamide
N-(a-Methylbenzyl)linoleamide
N-(2-methylbenzyl)linoleamide
N-(α-Methylbenzyl)linoleamide
DL-N-(a-Methylbenzyl)linoleamide
DL-N-(α-Methylbenzyl)linoleamide
DL-N-(α-Methylbenzyl)linoleamide
物理化學(xué)性質(zhì)
| 報(bào)價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-101722 | Melinamide | 14417-88-0 | 1 mg | 909元 |
| 2026/06/05 | HY-101722 | 甲亞油酰胺 Melinamide | 14417-88-0 | 5mg | 2000元 |
| 2026/06/05 | HY-101722 | Melinamide | 14417-88-0 | 10 mM * 1 mLin DMSO | 2200元 |
常見問題列表
IC50: 20.9 μM (cholesterol)
DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide.
Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment.