1446399-26-3
英文名稱
Imidazo[1,2-a]pyridine-2-carboxamide, N-[7-cyano-2,3-dihydro-1,1-dioxido-6-(trifluoromethyl)benzo[b]thien-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxy-
CAS
1446399-26-3
分子式
C30H27F4N5O4S
分子量
629.63
MOL 文件
1446399-26-3.mol
1446399-26-3 結(jié)構(gòu)式
基本信息
英文別名
Imidazo[1,2-a]pyridine-2-carboxamide, N-[7-cyano-2,3-dihydro-1,1-dioxido-6-(trifluoromethyl)benzo[b]thien-3-yl]-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxy-應(yīng)用領(lǐng)域
用途一
Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines.