1449240-68-9

中文名稱 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽

英文名稱 K145 (hydrochloride)

CAS 1449240-68-9

分子式 C18H25ClN2O3S

分子量 384.921

MOL 文件 1449240-68-9.mol

更新日期 2023/03/20 15:41:25

1449240-68-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽價格(試劑級) 常見問題列表

基本信息

中文別名

SPHK2抑制劑(K145鹽酸鹽)
3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽

英文別名

K145(HCl)
SphK2 inhibitor
K14 (hydrochloride)
K145 (hydrochloride)
K145 hydrochloride >=98% (HPLC)
SPHK2 INHIBITOR
K 145 HYDROCHLORIDE
K-145 HYDROCHLORIDE
3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1)

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

儲存條件2-8°C

溶解度在DMSO中的溶解度為20mg/mL，澄清

形態(tài)粉末

顏色白色至米色

InChI1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;

InChIKeyHADFDMGQKBGVAV-NKBLJONXSA-N

SMILESS1\C(=C/CCc2ccc(cc2)OCCCC)\C(=O)N(C1=O)CCN.Cl

安全數(shù)據(jù)

危險性符號(GHS) 腐蝕 (GHS05)

GHS05,GHS08

警示詞危險

危險性描述H315-H318-H334-H317-H341-H361-H370-H413

防范說明P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501

WGK Germany3

存儲類別11 - Combustible Solids

圖譜信息

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽(1449240-68-9)核磁圖(¹HNMR)

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽 K145 hydrochloride	1449240-68-9	5mg	418元
2026/06/05	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽 K145 hydrochloride	1449240-68-9	10mM * 1mLin DMSO	459元
2026/06/05	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亞丙基]-2,4-噻唑烷二酮鹽酸鹽 K145 hydrochloride	1449240-68-9	10mg	585元

常見問題列表

生物活性

K145 hydrochloride 是一種選擇性的，具有底物競爭性和口服活性的 SphK2 抑制劑，IC50 為 4.3 μM，Ki 為 6.4 μM。K145 hydrochloride 對 SphK1 和其他蛋白激酶沒有活性。K145 hydrochloride 可誘導(dǎo)細胞凋亡，并具有強大的抗腫瘤活性。

靶點

IC50: 4.3 μM (SphK2)
Ki: 6.4 μM (SphK2)

體外研究

K145 (0-10 μM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner.
K145 (10 μM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells.
K145 (4-8 μM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt.
Treatment with K145 (10 μM) causes a decrease of total cellular S1P without significant effects on ceramide levels.

Cell Viability Assay

Cell Line:	U937 cells
Concentration:	0 μM, 4 μM, 6 μM, 8 μM, 10 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Significantly inhibited the growth of U937 cells in a concentration-dependent manner.

Apoptosis Analysis

Cell Line:	U937 cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Significantly induced apoptosis in U937 cells.

Western Blot Analysis

Cell Line:	U937 cells
Concentration:	4 μM, 8 μM
Incubation Time:	3 hours
Result:	Phosphorylated ERK and Akt were decreased.

體內(nèi)研究

K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice.

Animal Model:	BALB/c-nu mice injected with U937 cells
Dosage:	50 mg/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.

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