1449367-94-5
中文名稱(chēng)
化合物 ACT-672125
英文名稱(chēng)
Ethanone, 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-[6-(5-methyl-1,2,4-oxadiazol-3-yl)-1H-benzimidazol-2-yl]-2-(trifluoromethyl)-5-thiazolyl]-1-piperazinyl]-
CAS
1449367-94-5
分子式
C25H25F3N10O2S
分子量
586.59
MOL 文件
1449367-94-5.mol
1449367-94-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 ACT-672125 英文別名
ACT-672125Ethanone, 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[4-[6-(5-methyl-1,2,4-oxadiazol-3-yl)-1H-benzimidazol-2-yl]-2-(trifluoromethyl)-5-thiazolyl]-1-piperazinyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)815.8±75.0 °C(Predicted)
密度1?+-.0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)8.57±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.