一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>1449597-34-5

1449597-34-5

中文名稱 1449597-34-5
英文名稱 SMN-C3
CAS 1449597-34-5
分子式 C24H28N6O
分子量 416.52
MOL 文件 1449597-34-5.mol
1449597-34-5 結(jié)構(gòu)式 1449597-34-5 結(jié)構(gòu)式

基本信息

中文別名
化合物SMN-C3
化合物 T12935
英文別名
SMN-C3
4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4,6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(1-ethyl-4-piperidinyl)-9-methyl-

物理化學(xué)性質(zhì)

密度1.31±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 5 mg/mL (12.00 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)9.27±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
1449597-34-5價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-112633SMN-C31449597-34-51 mg2200元
2026/06/05HY-1126331449597-34-5
SMN-C3
1449597-34-55mg5500元
2024/08/19HY-1126331449597-34-5
SMN-C3
1449597-34-510mg8500元

常見問題列表

生物活性
SMN-C3 是一種可口服的 SMN2 剪接調(diào)節(jié)劑,可用于脊椎肌肉萎縮 (SMA) 的研究。
靶點(diǎn)

SMN.

體內(nèi)研究

At P16, vehicle treated D7 mice are much smaller than heterozygous littermate controls and appear moribund. In contrast, D7 mice treated with the high dose of SMN-C3 show a phenotype similar to that of heterozygous controls. SMN-C3 treatment induces a dose-dependent bodyweight gain in the D7 mice, with some animals showing a body weight that is ~80% that of heterozygous controls. SMN-C3 normalizes the motor behavior of D7 mice, illustrated by the ability of the mice to right themselves as quickly as heterozygous controls and by their level of locomotor activity. Most importantly, whereas vehicle-treated mice die within 3 weeks after birth with a median survival of 18 days, SMN-C3 treatment increases survival in a dose-dependent manner to a median survival time of 28 days in the low-dose (0.3 mg/kg per day) group. In the two higher-dose groups (1 and 3 mg/kg per day), ~90% of animals survive beyond P65 when the study is completed.

"1449597-34-5" 相關(guān)產(chǎn)品信息
东明县| 民县| 台前县| 瑞丽市| 越西县| 革吉县| 吉安市| 定州市| 会泽县| 大城县| 卫辉市| 大荔县| 衡阳县| 皋兰县| 六安市| 仪陇县| 武功县| 长子县| 松滋市| 德安县| 东乡县| 房山区| 司法| 乌兰察布市| 卢龙县| 新巴尔虎右旗| 成都市| 蓝山县| 务川| 蛟河市| 襄垣县| 大丰市| 嘉鱼县| 三门峡市| 武强县| 东城区| 凉山| 武安市| 神木县| 江口县| 额敏县|