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14504-73-5

中文名稱 Tritoqualine
英文名稱 Tritoqualine
CAS 14504-73-5
分子式 C26H32N2O8
分子量 500.54
MOL 文件 14504-73-5.mol
14504-73-5 結(jié)構(gòu)式 14504-73-5 結(jié)構(gòu)式

基本信息

中文別名
酞茂異喹
英文別名
Tritocalin
Hypostamine
Inhibostamin
7-Amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
1(3H)-Isobenzofuranone, 7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-

物理化學(xué)性質(zhì)

熔點(diǎn)183°
沸點(diǎn)647.2±55.0 °C(Predicted)
密度1.296±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)6.22±0.40(Predicted)

常見問題列表

生物活性
Tritoqualine 是一種組氨酸脫羧酶抑制劑。
靶點(diǎn)

histidine decarboxylase

體外研究

The effect of Tritoqualine (TRQ) on the CCl 4 -induced enzyme leakage is investigated by pretreatment of rats with Tritoqualine (200 mg/kg/day, p.o., 7 days). The ratio of lactate dehydrogenase (LDH) release from the cells of Tritoqualine-pretreated rats is significantly less than that in control rats. The rate of malondialdehyde (MDA) production is accelerated after the addition of 7.8 mM CCl 4 . Tritoqualine reduces its rate in a dose dependent manner, and it completely prevents CCl 4 -stimulated lipid peroxidation at a concentration of 33 μM.

體內(nèi)研究

A single administration of CCl 4 (0.75 mL/kg, p.o.) causes a five-fold increase of in vivo lipid peroxidation in the liver. In contrast, a reduction of 37% in the lipid peroxidation is obtained by Tritoqualine (100 mg/kg) pretreatment for 14 days prior to CCl 4 treatment. A 63% reduction is observed in vitamin E (25 mg/kg) pretreated rats.

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