146670-40-8
中文名稱
SR 11237
英文名稱
SR 11237
CAS
146670-40-8
分子式
C24H28O4
分子量
380.48
MOL 文件
146670-40-8.mol
更新日期
2026/06/05 15:13:22
146670-40-8 結(jié)構(gòu)式
基本信息
中文別名
化合物SR11237化合物 T23383
英文別名
BMS649SR 11237
BMS 188649
4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid
Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-
所屬類(lèi)別
生物化工：抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO：>28mg/mL（加熱）
形態(tài)粉末
顏色白色至灰白色
InChI1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
InChIKeyZZUKALQMHNSWTK-UHFFFAOYSA-N
SMILESCC1(C)CCC(C)(C)c2cc(ccc12)C3(OCCO3)c4ccc(cc4)C(O)=O
SR 11237價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-107413 | SR11237 | 146670-40-8 | 1 mg | 800元 |
| 2026/06/05 | HY-107413 | SR 11237 SR11237 | 146670-40-8 | 5mg | 1900元 |
| 2026/06/05 | HY-107413 | SR 11237 SR11237 | 146670-40-8 | 10 mM * 1 mL in DMSO | 2090元 |
常見(jiàn)問(wèn)題列表
生物活性
SR11237 (BMS-649) 是一種視黃醇 X 受體 (RXR) 選擇性激動(dòng)劑，沒(méi)有任何 RAR 活性。SR11237可導(dǎo)致 RXR/RXR 同型二聚體形成并激活含有 RXR 反應(yīng)元件的報(bào)告基因。體外研究
Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors.
體內(nèi)研究
SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; daily from post-natal days 5 to 15 |
| Result: | Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |