1480830-24-7

中文名稱化合物 T28275

英文名稱 Carbamimidothioic acid, N-[4-(4-chlorophenyl)butyl]-, 3-(1-piperidinyl)propyl ester

CAS 1480830-24-7

分子式 C19H30ClN3S

分子量 367.98

MOL 文件 1480830-24-7.mol

1480830-24-7 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 應(yīng)用領(lǐng)域常見問題列表

基本信息

中文別名

化合物 T28275

英文別名

OUP186
OUP-186
OUP 186
Carbamimidothioic acid, N-[4-(4-chlorophenyl)butyl]-, 3-(1-piperidinyl)propyl ester

物理化學(xué)性質(zhì)

沸點490.3±55.0 °C(Predicted)

密度1.15±0.1 g/cm3(Predicted)

酸度系數(shù)(pKa)9.32±0.10(Predicted)

應(yīng)用領(lǐng)域

用途一

OUP-186 is a high affinity and humarat species-selective histamine H3 receptor antagonist. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.

常見問題列表

概述

OUP-186 是一種組胺 H3 受體拮抗劑。