149155-45-3
149155-45-3 結(jié)構(gòu)式
基本信息
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-P1595A | 多肽CREBtide CREBtide TFA | 149155-45-3 | 1 mg | 700元 |
| 2026/06/05 | HY-P1595A | 多肽CREBtide CREBtide TFA | 149155-45-3 | 5 mg | 2200元 |
| 2026/06/05 | HY-P1595A | 多肽CREBtide CREBtide TFA | 149155-45-3 | 10 mg | 3500元 |
常見問題列表
PKA
delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent K m of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (K m =39 μM), the synthetic peptide substrate most often employed for cAK measurement. The V max values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent K m of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the V max value is 3.2 mumol/(min.mg). Both delta-CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide.