1493762-74-5
1493762-74-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10563 英文別名
BM635Morpholine, 4-[[1-(4-fluorophenyl)-2-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrrol-3-yl]methyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)500.3±50.0 °C(Predicted)
密度1.12±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 31 mg/mL (78.98 mM)
酸度系數(shù)(pKa)6.70±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
BM635價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-109587 | BM635 BM635 | 1493762-74-5 | 5mg | 650元 |
| 2026/06/05 | HY-109587 | BM635 BM635 | 1493762-74-5 | 10 mM * 1 mLin DMSO | 715元 |
| 2026/06/05 | HY-109587 | BM635 BM635 | 1493762-74-5 | 10mg | 1050元 |
常見(jiàn)問(wèn)題列表
生物活性
BM635是 MmpL3 的抑制劑， 具有出色的抗分歧桿菌活性。抑制結(jié)合分歧桿菌H37Rv的MIC50 值為0.12 μM。靶點(diǎn)
MIC50: 0.12 μM (M. tuberculosis H37Rv)
體內(nèi)研究
BM635 has potent MIC (0.12 μM), Tox 50 :MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED 99 of 49 mg/Kg (IC 95% : 43–54 mg/Kg). The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (C max =1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo .