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150351-31-8

中文名稱 化合物 T28330
英文名稱 PD 135390
CAS 150351-31-8
分子式 C37H61N5O7S2
分子量 752.04
MOL 文件 150351-31-8.mol
150351-31-8 結(jié)構(gòu)式 150351-31-8 結(jié)構(gòu)式

基本信息

中文別名
化合物 T28330
英文別名
PD 135390

物理化學(xué)性質(zhì)

密度1.21±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)10.88±0.20(Predicted)

應(yīng)用領(lǐng)域

用途一
PD 135390 is a novel HIV-1 protease inhibitors identified by rational selection. The human immunodeficiency virus (HIV-1), associated with the AIDS (acquired immunodeficiency syndrome) epidemic, encodes an aspartyl protease that is essential for polyprotein processing in the virus (Navia et al., 1989). It has been demonstrated that inactivation of the protease either catalytically or by an inhibitor prevents infectious virion formation (Kohl et al., 1988; Darke et al., 1989). The acquired knowledge of key molecular interactions occurring between inhibitors and aspartyl proteases, as well as the structural similarities between HIV-1 protease and human renin was used to rationally select candidates for HIV-1 screening from the pool of analogs designed as renin inhibitors. A minimal number of chosen compounds were tested in an HIV-1 protease assay system. Two structurally novel peptides emerged as potent enzymatic protease inhibitors. This study highlights the selection process and characterizes the antiviral properties of the two novel analogs.

常見問題列表

概述
(Rac)-PD 135390 是一種二肽和 HIV-1 蛋白酶抑制劑,具有 2 nM 的 IC50 值。(Rac)-PD 135390 可用于抗病毒研究。
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