151165-96-7
151165-96-7 結(jié)構(gòu)式
基本信息
2-Naphthalenecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-, methyl ester
物理化學(xué)性質(zhì)
常見問題列表
IBAT
S-8921 is an ileal Na + /bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [ 3 H] taurocholate dose-dependently in IBAT-COS cells, and the IC 50 value of S-8921 is 66±8 μM.
Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective.