151533-34-5
中文名稱
ACOLBIFENE
英文名稱
ACOLBIFENE
CAS
151533-34-5
分子式
C29H31NO4
分子量
457.56
MOL 文件
151533-34-5.mol
更新日期
2023/03/20 15:41:33
151533-34-5 結構式
基本信息
中文別名
化合物 T12654 英文別名
ACOLBIFENE(Rac)-EM-652
rac-Acolbifene
2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
物理化學性質
沸點651.5±55.0 °C(Predicted)
密度1.217±0.06 g/cm3(Predicted)
溶解度DMSO: 100 mg/mL (218.55 mM)
酸度系數(shù)(pKa)9.70±0.40(Predicted)
形態(tài)Crystal
顏色Purple to purplish red
ACOLBIFENE價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 5mg | 890元 |
| 2026/06/05 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 10mM * 1mLin DMSO | 896元 |
| 2026/06/05 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 10mg | 1428元 |
常見問題列表
生物活性
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) 是 EM652 (estrogen receptor 拮抗劑) 的外消旋形式，具有抗雌激素和雌激素活性。 (Rac)-Acolbifene (EM-343; (Rac)-EM-652) 含哌啶環(huán)，具有良好的藥理作用，RBA=380。體外研究
(Rac)-Acolbifene (EM-343; (Rac)-EM-652)? shows a inhibitory effect in T-47D cells with an IC 50 value of 0.110 nM.
Cell Viability Assay
| Cell Line: | T-47D cells |
| Concentration: | 0.110 nM |
| Incubation Time: | 72 hours |
| Result: | Inhibited T-47D cells growth. |
體內(nèi)研究
(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).