153192-22-4
中文名稱(chēng)
YM 15430-1
英文名稱(chēng)
YM 15430-1
CAS
153192-22-4
分子式
C29H35N3O8
分子量
553.6
MOL 文件
153192-22-4.mol
153192-22-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)729.3±60.0 °C(Predicted)
密度1.240±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.98±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
YM-430, also known as YM-15430; YM-154301; is a dual of β1 adrenergic receptor antagonist and calcium channel antagonist. YM430 could be both an antianginal and antihypertensive agent, because of its dual activities. YM430 (10(-8)-10(-6) M) inhibited 3,4-diaminopyridine-induced rhythmic contractions with an IC50 value of 59.2 nM. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO. YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina.