1544739-76-5
中文名稱
化合物 MK-8666
英文名稱
Cyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, 3-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-5,5a,6,6a-tetrahydro-, (5aS,6R,6aR)-
CAS
1544739-76-5
分子式
C29H31NO6S
分子量
521.62
MOL 文件
1544739-76-5.mol
1544739-76-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 MK-8666 英文別名
Cyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, 3-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-5,5a,6,6a-tetrahydro-, (5aS,6R,6aR)-物理化學(xué)性質(zhì)
沸點(diǎn)741.8±60.0 °C(Predicted)
密度1.304±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)3.94±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.