154927-31-8
中文名稱
ZK118182 isopropyl ester
英文名稱
ZK118182 isopropyl ester
CAS
154927-31-8
分子式
C23H37ClO5
分子量
428.99
MOL 文件
154927-31-8.mol
154927-31-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T29225 英文別名
ZK118182 isopropyl esterQLJUNFBXIBNQOL-LMJZMJOFSA-N
ZK118182 isopropyl ester Exclusive
propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate
Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)
物理化學(xué)性質(zhì)
沸點(diǎn)553.1±50.0 °C(Predicted)
密度1.14±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
酸度系數(shù)(pKa)14.22±0.70(Predicted)
應(yīng)用領(lǐng)域
用途一
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-