155415-08-0
155415-08-0 結(jié)構(gòu)式
基本信息
中文別名
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H-314-27inogatran
Glycine, N-[(1R)-2-[(2S)-2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-
常見問題列表
生物活性
Inogatran (H-314-27) 是一種合成的 thrombin 抑制劑，主要用于預防動脈和靜脈血栓性疾病。體內(nèi)研究
Inogatran (H-314-27; 0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis.
Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model.