155415-08-0
155415-08-0 結(jié)構(gòu)式
基本信息
中文別名
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H-314-27inogatran
Glycine, N-[(1R)-2-[(2S)-2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-
物理化學(xué)性質(zhì)
密度1.36±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)2.16±0.10(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
Inogatran (H-314-27) 是一種合成的 thrombin 抑制劑，主要用于預(yù)防動(dòng)脈和靜脈血栓性疾病。體內(nèi)研究
Inogatran (H-314-27; 0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis.
Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model.