15585-43-0
中文名稱
(E)-位變異煙堿
英文名稱
rivanicline
CAS
15585-43-0
分子式
C10H14N2
分子量
162.232
MOL 文件
15585-43-0.mol
更新日期
2024/10/09 14:23:16
15585-43-0 結(jié)構(gòu)式
基本信息
中文別名
(E)-位變異煙堿 英文別名
rivaniclineUnii-6H35lf645a
(E)-Metanicotine
trans-Metanicotine
RIVANICLINE
METANICOTINE
RJR 2403
(E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine
(3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine
3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (3E)-
But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-
(E)-N-[Methyl]-4-(3-pyridinyl)-3-buten-1-aMine, RJR 2403
物理化學(xué)性質(zhì)
沸點(diǎn)99-101°C/0.4mm Hg
密度0.980
閃點(diǎn)130℃
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)10.03±0.10(Predicted)
形態(tài)粉末
穩(wěn)定性Hygroscopic
應(yīng)用領(lǐng)域
用途1
An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer鈥檚 type and currently being
investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to periphera
l ganglionic and muscle-type nicotinic acetylcholine receptors.