156722-18-8

中文名稱(chēng) ROSTAFUROXIN

英文名稱(chēng) (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

CAS 156722-18-8

分子式 C23H34O4

分子量 374.51

MOL 文件 156722-18-8.mol

更新日期 2026/06/05 17:25:51

156722-18-8 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 圖譜信息 ROSTAFUROXIN價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

(3Β,?5Β,?14Β)?-?21,23-環(huán)氧-24-降膽固醇-20,22-二烯-3,14,17-三醇

英文別名

CS-906
PST2238
17-triol
AC1L4BGU
Rostafuroxin
CHEMBL2068971
SureCN1716210
UNII-P848LCX62B
PST 2238, >=98%
PST2238,Rostafuroxin

所屬類(lèi)別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)451.3±45.0 °C(Predicted)

密度1.226±0.06 g/cm3(Predicted)

儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C

溶解度insoluble in H2O; insoluble in EtOH; ≥12.05 mg/mL in DMSO

酸度系數(shù)(pKa)14.02±0.70(Predicted)

形態(tài)固體

顏色White to off-white

圖譜信息

ROSTAFUROXIN(156722-18-8)核磁圖(¹HNMR)

ROSTAFUROXIN價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-12283	Rostafuroxin	156722-18-8	1 mg	300元
2026/06/05	HY-12283	ROSTAFUROXIN Rostafuroxin	156722-18-8	5mg	750元
2026/06/05	HY-12283	ROSTAFUROXIN Rostafuroxin	156722-18-8	10mM * 1mLin DMSO	825元

常見(jiàn)問(wèn)題列表

生物活性

Rostafuroxin (PST 2238) 是一種洋地黃毒苷衍生物，一種口服有效的 Na+,K+-ATPase (ATP1A1) 抑制劑。Rostafuroxin 與 ATP1A1 胞外域特異性結(jié)合，并阻斷呼吸道合胞病毒 (RSV) 觸發(fā)的 EGFR Tyr845 磷酸化。Rostafuroxin 具有抗高血壓和抗 RSV 活性。

體外研究

Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling. Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced, Src-dependent Na ⁺ ,K ⁺ -ATPase phosphorylation and activation.
Rostafuroxin (0.125-128 μM; for 24 h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC. Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC ₅₀ =1.8 μM) and A549 cells (IC ₅₀ =14.8 μM).
Rostafuroxin displaced [ ³ H]Ouabain from the dog kidney Na ⁺ ,K ⁺ -ATPase receptor (IC50=1.5 nM), is devoid of cardiac inotropic activity in isolated guinea pig atria, and shows no affinity up to 10 ^-4 M with general (R1, R2, a1, a2, A1, A2, M1, M2, H1, H2, 5-HT1, 5-HT2, Ca2+ channels, TXA2/PGH2, PAF, GABAA, GABAB, DA-NE-5-HT uptake, glutammate,glycine, benzodiazepine) and hormonal (estrogenic, progestinic, androgenic, mineralcorticoid) receptors.

體內(nèi)研究

Rostafuroxin (PST 2238; 1 mg/kg/day; gavage; for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation.