157000-76-5
中文名稱
化合物T7747
英文名稱
Datelliptium chloride hydrochloride
CAS
157000-76-5
分子式
C23H28ClN3O
分子量
397.95
MOL 文件
157000-76-5.mol
157000-76-5 結(jié)構(gòu)式
基本信息
中文別名
化合物T7747化合物 DATELLIPTIUM CHLORIDE HYDROCHLORIDE
英文別名
Datelliptium chloride hydrochlorideantitumoral,Datelliptium chloride hydrochloride,DNA/RNA Synthesis,activity,Inhibitor,Ellipticine,hepatotoxicity,inhibit,Datelliptium chloride,antineoplastic
物理化學(xué)性質(zhì)
溶解度DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
Ethanol: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
常見問題列表
生物活性
Datelliptium chloride hydrochloride 是一種由 Ellipticine (HY-15753) 衍生的 DNA 嵌合劑。Datelliptium chloride hydrochloride 在體內(nèi)對多種小鼠實體瘤有效。體外研究
Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.
體內(nèi)研究
Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210.
| Animal Model: | Mice, colon adenocarcinoma early staged disease model |
| Dosage: | 170 mg/kg |
| Administration: | Intravenous injection, for 12 days |
| Result: | Highly active against colon adenocarcinoma. |