158089-95-3
158089-95-3 結(jié)構(gòu)式
基本信息
2,6-ditert-butyl-4-[(2-ethyl-1,1-dioxo-1,2-thiazolidin-5-ylidene)methyl]phenol
Phenol, 2,6-bis(1,1-dimethylethyl)-4-[(E)-(2-ethyl-1,1-dioxido-5-isothiazolidinylidene)methyl]-
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
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COX-2 11 nM (IC 50 ) |
COX-1 27 μM (IC 50 ) |
5-LO
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S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, with IC 50 s of 11 nM and 27 μM for COX-2 and COX-1. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC 50 =26±12?nM). S-2474 (10?μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 inhibits the PGD2 generation in a concentration dependent manner (IC 50 =69.8±21.9?nM). S-2474 (10?μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons. S-2474 significantly prevents neurons from undergoing sPLA 2 -IIA-induced cell death. S-2474 completely ameliorates sPLA 2 -IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. Moreover, S-2474 significantly inhibits the sPLA 2 -IIA-induced generation of PGD2. S-2474 inhibits sPLA 2 -IIA-induced neuronal cell death in a concentration-dependent manner (IC 50 = 94 nM).