一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>15866-90-7

15866-90-7

中文名稱 INCYCLINIDE (CMT-3, COL-3)
英文名稱 Incyclinide
CAS 15866-90-7
分子式 C19H17NO7
分子量 371.34
MOL 文件 15866-90-7.mol
更新日期 2026/01/08 13:18:02
15866-90-7 結(jié)構(gòu)式 15866-90-7 結(jié)構(gòu)式

基本信息

中文別名
MMP抑制劑(INCYCLINIDE)
英文別名
COL 3
CMT 3
Metastat
NSC 683551
Incyclinide
INCYCLINIDE (CMT-3, COL-3)
2-NaphthacenecarboxaMide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4aS,5aR,12aS)-

物理化學(xué)性質(zhì)

熔點(diǎn)228-231 °C
沸點(diǎn)752.8±60.0 °C(Predicted)
密度1.70±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO:100.0(Max Conc. mg/mL);269.29(Max Conc. mM)
酸度系數(shù)(pKa)4.50±1.00(Predicted)
形態(tài)固體
顏色Light yellow to yellow
INCYCLINIDE (CMT-3, COL-3)價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2026/06/05HY-13648INCYCLINIDE (CMT-3, COL-3)
Incyclinide
15866-90-71mg780元
2026/06/05HY-13648INCYCLINIDE (CMT-3, COL-3)
Incyclinide
15866-90-75mg1200元
2026/06/05HY-13648INCYCLINIDE (CMT-3, COL-3)
Incyclinide
15866-90-710mM * 1mLin DMSO1320元

常見問題列表

生物活性
Incyclinide (CMT-3, COL-3) 是一種基質(zhì)金屬蛋白酶 (MMP) 抑制劑,誘導(dǎo)細(xì)胞外基質(zhì)降解,抑制血管生成,腫瘤生長和侵襲以及轉(zhuǎn)移。
體外研究

Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%.

體內(nèi)研究

Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix.

"15866-90-7" 相關(guān)產(chǎn)品信息
808-26-4 2444-65-7 23313-80-6 3963-95-9 1035655-10-7 171807-99-1
台湾省| 高阳县| 尚志市| 新巴尔虎右旗| 许昌市| 黄浦区| 柳州市| 本溪市| 开江县| 满洲里市| 丹寨县| 张家港市| 吉林省| 莱阳市| 黑河市| 门源| 进贤县| 政和县| 远安县| 通海县| 开化县| 盐池县| 任丘市| 河北省| 临西县| 夏河县| 乌兰县| 高邮市| 翼城县| 行唐县| 萍乡市| 高雄县| 隆安县| 海原县| 达拉特旗| 许昌市| 永清县| 桑植县| 乾安县| 清新县| 开平市|