1596362-29-6
中文名稱(chēng)
(S)-N-((S)-1-((環(huán)己基甲基)氨基)-5-胍基-1-氧代戊烷-2-基)-2-(4-氧代-4-苯基丁?；?-1,2,3,4-四氫異喹啉-3-甲酰胺鹽酸鹽
英文名稱(chēng)
PS372424 hydrochloride
CAS
1596362-29-6
分子式
C33H45ClN6O4
分子量
625.21
MOL 文件
1596362-29-6.mol
1596362-29-6 結(jié)構(gòu)式
基本信息
中文別名
(S)-N-((S)-1-((環(huán)己基甲基)氨基)-5-胍基-1-氧代戊烷-2-基)-2-(4-氧代-4-苯基丁酰基)-1,2,3,4-四氫異喹啉-3-甲酰胺鹽酸鹽 英文別名
PS372424 hydrochloride常見(jiàn)問(wèn)題列表
生物活性
PS372424 hydrochloride，CXCL10 的三個(gè)氨基酸片段，是一種特異的人 CXCR3 激動(dòng)劑，具有抗炎活性。在關(guān)節(jié)炎炎癥模型中，PS372424 hydrochloride 可抑制 T 細(xì)胞遷移。靶點(diǎn)
|
Human CXCR3
|
體外研究
PS372424 (100?ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5?min of stimulation.
PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3
+
T cells not in CXCR3
-
T cells.
PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC
50
of 42±21 nM.
Western Blot Analysis
| Cell Line: | CXCR3 + T cells and CXCR3 - T cells |
| Concentration: | 10, 50, 100, or 200 nM |
| Incubation Time: | 30 minutes |
| Result: | Caused a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells. Did not result in phosphorylation of CCR5 on CXCR3 - T cells. |