15966-93-5
中文名稱
VEGFR2 KISE INHIBITOR I
英文名稱
VEGFR2 Kinase Inhibitor I
CAS
15966-93-5
分子式
C18H18N2O3
分子量
310.35
MOL 文件
15966-93-5.mol
更新日期
2026/05/25 08:41:27
15966-93-5 結(jié)構(gòu)式
基本信息
中文別名
RAMUCIRUMAB ( 雷莫蘆單抗 )化合物VEGFR2 KINASE INHIBITOR I
2,4-二甲基-5-((2-氧吲哚-3-亞甲基)甲基)-1H-吡咯-3-羧酸乙酯
英文別名
SU5408VEGFR2 TK Inhibitor
SU 5408
SU-5408
SU5408
VEGFR2 KISE INHIBITOR I
VEGFR2 Kinase Inhibitor I
VEGFR2 kinase inhibitor I(SU-5408)
1H-Pyrrole-3-carboxylic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-, ethyl ester
物理化學(xué)性質(zhì)
沸點571.4±50.0 °C(Predicted)
密度1.271±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Store in freezer, under -20°C
溶解度DMF: 1 mg/ml; DMSO: 1 mg/ml
酸度系數(shù)(pKa)12.40±0.20(Predicted)
形態(tài)結(jié)晶固體
顏色Yellow to orange
VEGFR2 KISE INHIBITOR I價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | S6514 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 5mg | 2678.13元 |
| 2026/03/03 | S6514 | SU5408 | 15966-93-5 | 25mg | 7944.3元 |
| 2025/12/22 | HY-103002 | VEGFR2 KISE INHIBITOR I SU5408 | 15966-93-5 | 1 mg | 800元 |
常見問題列表
生物活性
SU5408 (VEGFR2 Kinase Inhibitor I)是一種有效、選擇性 VEGFR2 Kinase抑制劑，IC50為70 nM。靶點
| Target | Value |
|
VEGFR2
(Cell-free assay) | 70 nM |
體外研究
3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 (VEGFR2 Kinase Inhibitor I) is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 (VEGFR2 Kinase Inhibitor I) shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC 50 >100 μM).