1597438-92-0
中文名稱
化合物 T26896
英文名稱
BRD1652
(BRD 1652)
CAS
1597438-92-0
分子式
C20H20F3N3O
分子量
375.39
MOL 文件
1597438-92-0.mol
1597438-92-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T26896 英文別名
BRD1652BRD1652 (BRD 1652)
5H-Pyrazolo[3,4-b]quinolin-5-one, 1,2,4,6,7,8-hexahydro-4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-, (4S)-
應(yīng)用領(lǐng)域
用途一
BRD1652 is a highly selective and potent GSK3 inhibitor. BRD1652 demonstrates in vivo efficacy in a dopaminergic signaling paradigm modeling mood-related disorders. The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3).