159752-10-0
159752-10-0 結(jié)構(gòu)式
基本信息
伊布莫侖甲磺酸鹽
伊布莫倫甲磺酸鹽
MK-677 馬來酸鹽
MK677 POWDER
伊布莫侖甲磺酸鹽(MK-677)
Ibutamoren mesilate
MK677 MK 677 IBUTAMOREN
MK677（Ibutamoren Mesylate）
nicotinamide mononucleotide powder
MK-677
CRESCENDO
MK 0677
MK-0677
MK0677
MK677
MK 677
MK-667
CS-1402
MK-0667
nutrobal
物理化學(xué)性質(zhì)
常見問題列表
伊布莫侖甲磺酸鹽是一種藥物，它作為一個強(qiáng)有力的，口服有效的促生長激素分泌，模仿gh刺激內(nèi)源性激素的作用。
伊布莫侖甲磺酸鹽已被證實(shí)能增加的釋放,并產(chǎn)生持續(xù)增加等離子體水平的一些激素包括gh和胰島素樣生長因子1(igf - 1),但不影響皮質(zhì)醇水平。目前正在開發(fā)的潛在治療減少了這些激素的水平,比如在兒童或老年人與生長激素缺乏癥,和人類研究顯示增加肌肉和骨礦物質(zhì)密度,使之成為一個有前途治療虛弱的老人。它也改變體內(nèi)脂肪的代謝,所以可能在肥胖的治療中的應(yīng)用。
Ibutamoren mesylate (MK-0667, L-163191)是一種口服有效的的生長激素（GH)促分泌素，是一種有效的非肽饑餓素受體激動劑。
Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum IGF-1 and GH levels in dogs. Ibutamoren mesylate results in no significant increase in CSF IGF-1 or GH levels on days 7 or 15 of the study. Pretreating mice with GH blocks activation of these neurons by Ibutamoren mesylate (50 μg, i.p.). In the knockout mice, both GH and octreotide fail to inhibit Ibutamoren mesylate activation of arcuate neurons. Chronic oral administration of MK-0677 is associated with significant increases in GH and IGF-I levels that are maintained for the duration of the treatment. The GH profile following MK-0677 administration consists of episodic increases above control. MK-0677 significantly increases peak GH concentrations after oral administration. MK-0677 is a potent GH secretagogue that induces an immediate, large, long lasting increase in GH levels when administered orally or i.v.