160928-38-1
中文名稱
6-N,N-二乙基-Β-Γ-二溴亞甲基-D-腺苷E-5'-三磷酸鈉水合物
英文名稱
6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP
CAS
160928-38-1
分子式
C15H24Br2N5O12P3
分子量
719.11
MOL 文件
160928-38-1.mol
更新日期
2023/03/20 15:41:20
160928-38-1 結(jié)構(gòu)式
基本信息
中文別名
6-N,N-二乙基-Β-Γ-二溴亞甲基-D-腺苷E-5'-三磷酸鈉水合物 英文別名
ARL-67156FPL-67156
FPL 67156 TRISODIUM
ARL 67156 TRISODIUM
ARL 67156 TRISODIUM SALT
ARL 67156 trisodium salt hydrate
6-N,N-Diethyl-D-b,g-dibromomethyleneATP
6-N,N-Diethyl-D-B,G-Dibromomethyleneatp Tri
6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP
6-N,N-Diethyl-D-β,γ-dibromomethyleneATPtrisodiumsalt
物理化學(xué)性質(zhì)
沸點(diǎn)879.6±75.0 °C(Predicted)
密度2.32±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度H2O: 10 mg/mL
酸度系數(shù)(pKa)0.82±0.50(Predicted)
形態(tài)solid
顏色off-white
水溶解性H2O: >20mg/mL
DMSO: insoluble
DMSO: insoluble
InChIKeyUWMONIJVKGTUGE-OPKBHZIBSA-K
SMILESO.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
6-N,N-二乙基-Β-Γ-二溴亞甲基-D-腺苷E-5'-三磷酸鈉水合物價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-103265 | 6-N,N-二乙基-Β-Γ-二溴亞甲基-D-腺苷E-5'-三磷酸鈉水合物 ARL67156 trisodium salt | 160928-38-1 | 1mg | 1800元 |
| 2025/12/22 | HY-103265 | 6-N,N-二乙基-Β-Γ-二溴亞甲基-D-腺苷E-5'-三磷酸鈉水合物 ARL67156 trisodium | 160928-38-1 | 5 mg | 5400元 |
| 2024/04/30 | HY-103265B | 6-N,N-二乙基-Β-Γ-二溴亞甲基-D-腺苷E-5'-三磷酸鈉水合物 ARL67156 trisodium salt hydrate | 160928-38-1 | 1mg | 1800元 |
常見問題列表
生物活性
ARL67156 trisodium salt hydrate 是一種 ecto-ATPase 抑制劑。ARL67156 trisodium salt hydrate 是弱的競爭性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制劑，Ki 分別為 11，18 和 12 μM。ARL67156 trisodium salt hydrate 可預(yù)防體內(nèi)主動脈瓣鈣化。靶點(diǎn)
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
體外研究
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
體內(nèi)研究
Pre-treatment of mice with ARL67156 (2?mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100?mg/kg).
| Animal Model: | C57BL/6 mice |
| Dosage: | 2?mg/kg |
| Administration: | Pre-treated (i.p.) 1 ?h before administration of FBP (100?mg/kg) |
| Result: | Completely prevented the increase of serum adenosine concentration induced by FBP. |