1621535-90-7
中文名稱
化合物UCM-1336
英文名稱
Propanamide, 3,3'-(octylimino)bis[N-phenyl-
CAS
1621535-90-7
分子式
C26H37N3O2
分子量
423.59
MOL 文件
1621535-90-7.mol
1621535-90-7 結(jié)構(gòu)式
基本信息
中文別名
化合物UCM-1336 英文別名
UCM-13363,3′-(Octylimino)bis[N-phenylpropanamide]
Propanamide, 3,3'-(octylimino)bis[N-phenyl-
物理化學(xué)性質(zhì)
沸點(diǎn)644.2±40.0 °C(Predicted)
密度1.089±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)14.43±0.70(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應(yīng)用領(lǐng)域
用途一
UCM-1336 is a potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor ( IC50 = 2 μM). UCM-1336 improves survival in Ras-driven acute myeloid leukemia. UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia.