1623194-37-5
1623194-37-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13550 英文別名
2H-1-Benzopyran-7-propanoic acid, β-cyclopropyl-2-[2-fluoro-4-(2-methoxy-4-pyridinyl)phenyl]-3,4-dihydro-α-methyl-, (αS,βR,2S)-物理化學(xué)性質(zhì)
沸點(diǎn)596.7±50.0 °C(Predicted)
密度1.262±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.63±0.11(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
AP5 是一種有效的選擇性 GPR40 受體激動(dòng)劑，在大鼠 hIP1 實(shí)驗(yàn)中，AP5 作用于 GPR40 受體，EC50 為 0.49±0.28 nM。靶點(diǎn)
EC50: 0.49±0.28 nM (GPR40 Receptor)
體外研究
AP5 is a potent and selective GPR40 AgoPAM that demonstrates excellent in vivo efficacy. In the GK rat oral glucose tolerance test (oGTT), oral administration of AP5 1 h before an oral dextrose challenge shows that AP5 significantly reduces blood glucose levels compared to the vehicle. AP5 is determined to be more efficacious in this model, demonstrating maximally efficacious glucose lowering at a plasma concentration of 4.9 μM at 10 mg/kg.