162358-96-5
中文名稱
蘇戈莫德雜質(zhì)8
英文名稱
Fingolimod Impurity 8
CAS
162358-96-5
分子式
C16H25I
分子量
344.27
MOL 文件
162358-96-5.mol
162358-96-5 結構式
基本信息
中文別名
1-?(2-?碘乙基)?-?2-?辛基苯 英文別名
Fingolimod Impurity 72-octylphenethyl iodide
1-?(2-?Iodoethyl)?-?2-?octylbenzene
應用領域
用途一
1-?(2-?Iodoethyl)?-?2-?octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).