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162359-55-9

中文名稱 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
英文名稱 Gilenia
CAS 162359-55-9
分子式 C19H33NO2
分子量 307.47
MOL 文件 162359-55-9.mol
更新日期 2026/06/08 20:05:55
162359-55-9 結(jié)構(gòu)式 162359-55-9 結(jié)構(gòu)式

基本信息

中文別名
芬戈莫德堿
芬戈莫德-D4
芬格莫德及中間體
芬戈莫德 FINGOLIMOD
2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
英文別名
Gilenia
Fingolise
fingolimo
fenogliMod
Fingolimod
FingoliMod-D4
FingoliMod Base
Gilenia USP/EP/BP
Fingolimod(FTY720)
Gilenya(Fingolise)
所屬類別
生物化工:植物提取物

物理化學(xué)性質(zhì)

熔點(diǎn)103-105°
沸點(diǎn)479.5±45.0 °C(Predicted)
密度1.016
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度氯仿(稍微加熱)、DMSO(稍微加熱)、甲醇(稍微加熱)
酸度系數(shù)(pKa)12.20±0.20(Predicted)
形態(tài)固體
顏色米白色
InChIInChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChIKeyKKGQTZUTZRNORY-UHFFFAOYSA-N
SMILESC(O)C(N)(CCC1=CC=C(CCCCCCCC)C=C1)CO

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)有害 (GHS07)
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335-H402-H412
WGK GermanyWGK 3
存儲(chǔ)類別11 - Combustible Solids
危險(xiǎn)性類別Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Repr. 2
Skin Irrit. 2
STOT RE 2
2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-11063R2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
Fingolimod (Standard)
162359-55-910 mg360元
2026/06/05HY-11063R2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
Fingolimod (Standard)
162359-55-925 mg660元
2026/06/05HY-11063R2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
Fingolimod (Standard)
162359-55-950 mg1000元

常見(jiàn)問(wèn)題列表

生物活性
Fingolimod (FTY-720A, FTY-720)是S1PR調(diào)節(jié)劑,用于治療緩解型多發(fā)性硬化癥。
靶點(diǎn)
TargetValue
S1P receptor
()
體外研究

The monocyte-derived immature dendritic cells (iDCs) are pretreated with various concentrations of S1P for various periods of time prior to their incubation with NK cells. Four hours incubation of autologous or allogeneic iDCs with 0.2-20 μM of S1P significantly protectes these cells from NK cell lysis. The IC 50 values of S1P are calculated at 160 nM for autologous iDCs, and 34 nM for allogeneic iDCs. Next, the inhibitory effect of S1P is revered by various concentrations of Fingolimod or SEW2871, with an IC 50 effect of 173 or 15 nM, respectively. Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin. Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth. Additionally, Fingolimod significantly reduces LPA levels in the injured nerve. PF-8380 treatment correlates with improved myelin thickness.

體內(nèi)研究

Fingolimod treatment results in significantly increased nerve conduction at 14 days post-crush in wildtype C57BL/6 mice. However, Foxn1 -/- mice, which are devoid of T- but not B-lymphocytes, show an improvement of nerve regeneration under fingolimod treatment. Although the mean increase in nerve conduction velocity in both fingolimod-treated and control Foxn1 -/- mice implies a potentially positive role of T-lymphocyte deficiency on nerve regeneration, only fingolimod-treated Foxn1 -/- mice show a significant improvement compared to C57BL/6 controls and performed better in the functional analysis. Treatment of the animals with Fingolimod for 28 d results in a clear reduction in the binding of 18 F-GE180 when compare with vehicle-treated animals and evaluated by ex vivo autoradiography. Quantification of the binding of the radiotracer revealed a significant reduction in the binding potential of 18 F-GE180 (P<0.0001) after treatment with Fingolimod.

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