1623747-97-6
中文名稱
CRANAD 28
英文名稱
CRANAD 28
CAS
1623747-97-6
分子式
C27H23BF2N4O2
分子量
484.305
MOL 文件
1623747-97-6.mol
更新日期
2024/07/23 09:31:06
1623747-97-6 結(jié)構(gòu)式
基本信息
中文別名
4-[(E)-2- [2,2-二氟-6- [2-(5-甲基-1-苯基吡唑-1-基-4-亞烷基)亞乙基]亞乙基] -1,3-二氧雜-2-硼烷環(huán)己基 -4-EN-4-YL]乙烯基] -5-甲基-1-苯基吡唑 英文別名
CRANAD 284-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
所屬類別
醫(yī)藥中間體：雜環(huán)化合物物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
形態(tài)結(jié)晶固體
顏色Orange to red
InChIInChI=1S/C27H23BF2N4O2/c1-20-22(18-31-33(20)24-9-5-3-6-10-24)13-15-26-17-27(36-28(29,30)35-26)16-14-23-19-32-34(21(23)2)25-11-7-4-8-12-25/h3-19H,1-2H3
InChIKeyDDFFGVTUEQJYQK-UHFFFAOYSA-N
SMILESCC1=C(C=NN1C1C=CC=CC=1)C=CC1=O[B+3]([F-])([F-])O=C(C=CC2C=NN(C3C=CC=CC=3)C=2C)[CH-]1
應(yīng)用領(lǐng)域
用途一
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.