162704-20-3
162704-20-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T19597 英文別名
UK-1571473(2H)-Pyridazinone, 6-[[(3S,4R)-3,4-dihydro-3-hydroxy-6-[(3-hydroxyphenyl)sulfonyl]-2,2,3-trimethyl-2H-1-benzopyran-4-yl]oxy]-2-methyl-
物理化學(xué)性質(zhì)
熔點(diǎn)138-165 °C
沸點(diǎn)659.2±65.0 °C(Predicted)
密度1.40±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)8.51±0.10(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
UK-157147 是一種 UDP-葡萄糖醛酸轉(zhuǎn)移酶 (UGT1A1) 的底物，Km 值為 105 μM。靶點(diǎn)
Km: 105 μM (UGT1A1)
體外研究
Glucuronidation is an important pathway for human drug metabolism. Four cloned and expressed human UDP-glucuronosyltransferases (UGT1A1, UGT1A6, UGT1A9, and UGT2B15) are used to screen a series of three potential drug substrates differing only in position of the phenol moiety. The para phenol UK-157147 (UK-157,147) is found to be a substrate for UGT1A1 with a K m value of 105 μM.