1627503-67-6
1627503-67-6 結(jié)構(gòu)式
基本信息
中文別名
化合物L(fēng)DN-214117ALK2抑制劑(LDN-214117)
英文別名
CS-1539LDN-214117
LDN-214117 USP/EP/BP
LDN-214117
LDN214117
1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine
1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine
Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-
所屬類別
生物化工：TGF-beta/Smad 抑制劑物理化學(xué)性質(zhì)
沸點567.9±50.0 °C(Predicted)
密度1.134±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM)
酸度系數(shù)(pKa)8.86±0.10(Predicted)
形態(tài)粉末
顏色Light yellow to yellow
InChI1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3
InChIKeyBHUXVRVMMYAXKN-UHFFFAOYSA-N
SMILESCC(C(C1=CC(OC)=C(OC)C(OC)=C1)=C2)=NC=C2C(C=C3)=CC=C3N4CCNCC4
常見問題列表
生物活性
LDN-214117是一種有效的選擇性 BMP I型受體激酶 ALK2 抑制劑，IC50為 24 nM。體外研究
The kinase most highly inhibited by LDN-214117 is ALK2 (IC50, 24 nM), followed by TNIK, RIPK2, and ABL1. LDN-214117 demonstrates selective inhibition of ALK2 and ALK1 in preference to ALK3 kinase activity. LDN-214117 exhibits relatively selective inhibition of BMP6 versus BMP2 or BMP4. In a cell-based assay, LDN-214117 exhibits a selective inhibition on BMP6 with IC50 of approximately 100 nM, and 164-fold selectivity for BMP6 versus TGF-β1.