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1638750-95-4

中文名稱 ADU-S100 DISODIUM SALT
英文名稱 c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
CAS 1638750-95-4
分子式 C20H25N10NaO10P2S2
分子量 714.54
MOL 文件 1638750-95-4.mol
更新日期 2026/05/22 08:53:53
1638750-95-4 結(jié)構(gòu)式 1638750-95-4 結(jié)構(gòu)式

基本信息

中文別名
化合物 T10252
ADU-S100二鈉鹽
英文別名
ADU-S100 (MIW815)
MIW815 disodium salt
ADU-S100 disodium salt
ML RR-S2 CDA Sodium Salt
ML RR-S2 CDA disodium salt
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Water: Sparingly soluble: 1-10 mg/ml
形態(tài)Solid
顏色White to off-white
水溶解性Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH)
ADU-S100 DISODIUM SALT價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/12/22HY-12885AADU-S100 DISODIUM SALT
ADU-S100 disodium salt
1638750-95-41mg3300元
2023/03/20HY-12885AADU-S100 DISODIUM SALT
ADU-S100 disodium salt
1638750-95-45mg12000元
2023/03/20HY-12885AADU-S100 DISODIUM SALT
ADU-S100 disodium salt
1638750-95-410mg20000元

常見問題列表

生物活性
ADU-S100 disodium salt (MIW815 disodium salt) 是干擾素基因刺激物的激活劑 (STING),具有有效的抗腫瘤和免疫活性。
靶點(diǎn)

STING

體外研究

ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.

體內(nèi)研究

ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.

"1638750-95-4" 相關(guān)產(chǎn)品信息
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