1638851-44-1
1638851-44-1 結(jié)構(gòu)式
物理化學性質(zhì)
沸點597.7±50.0 °C(Predicted)
密度1.43±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.54±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
應用領域
用途一
HSK0935 is a potent and highly selective SGLT2 inhibitors (IC50 (hSGLT2) = 1.3 nM; IC50 (hSGLT1) + 1096nM). HSK0935 demonstrated excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold. It showed robust urinary glucose excretion in Sprague-Dawley (SD) rats and affected more urinary glucose excretion in Rhesus monkeys.