1640972-35-5
中文名稱
托法替尼雜質(zhì) 6
英文名稱
Tofacitinib Impurity 6
CAS
1640972-35-5
分子式
C16H22N6O
分子量
314.39
MOL 文件
1640972-35-5.mol
更新日期
2025/08/28 19:43:48
1640972-35-5 結(jié)構(gòu)式
基本信息
中文別名
M8加氫雜質(zhì)托法替尼雜質(zhì) 6
托法替布雜質(zhì)C對(duì)照品
托法替尼相關(guān)化合物21
托法替布相關(guān)化合物21
枸櫞酸托法替布雜質(zhì)21
枸櫞酸托法替布雜質(zhì) PF-05091895
N-甲基-N-((3S,4R)-4-甲基哌啶-3-基)-7H-吡咯并[2,3-D]嘧啶-4-胺 (M7非對(duì)映異構(gòu)體B)
英文別名
Tofacitinib-215,6-Dihydro CP-690550
Tofacitinib Impurity 39
Tofacitinib Related Compound 21
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine
(3R,4R)-3-[(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methyl-β-oxo-1-piperidinepropanenitrile
1-Piperidinepropanenitrile, 3-[(6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methyl-β-oxo-, (3R,4R)-
3-((3R,4R)-3-((6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
Tofacitinib impurity 14/5,6-Dihydro Tofacitinib/3-((3R,4R)-3-((6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
Tofacitinib impurity 15/5,6-Dihydro Tofacitinib Citrate/3-((3R,4R)-3-((6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate
物理化學(xué)性質(zhì)
熔點(diǎn)>80°C (dec.)
沸點(diǎn)583.2±50.0 °C(Predicted)
密度1.239±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)6.04±0.60(Predicted)
形態(tài)固體
顏色淡黃色至黃色
