1643947-30-1
中文名稱
ZEN 3694
英文名稱
1H-Imidazo[4,5-b]pyridin-2-amine, 6-(3,5-dimethyl-4-isoxazolyl)-N-methyl-1-(phenylmethyl)-
CAS
1643947-30-1
分子式
C19H19N5O
分子量
333.39
MOL 文件
1643947-30-1.mol
更新日期
2026/07/08 14:58:42
1643947-30-1 結(jié)構(gòu)式
物理化學性質(zhì)
沸點539.0±60.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)7.38±0.30(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應用領(lǐng)域
用途一
ZEN-3694 is an orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ZEN-3694 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression.