164658-13-3
164658-13-3 結(jié)構(gòu)式
基本信息
3-((4-(2-((3-氯苯基)氨基)嘧啶-4-基)吡啶-2-基)氨基)丙-1-醇
3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇
CGP 60474
CGP-60474
CGP 60474
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
1-Propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-11009 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 CGP60474 | 164658-13-3 | 1 mg | 360元 |
| 2026/06/05 | HY-11009 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 CGP60474 | 164658-13-3 | 5mg | 850元 |
| 2026/06/05 | HY-11009 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 CGP60474 | 164658-13-3 | 10mM * 1mLin DMSO | 935元 |
常見問題列表
|
CDK1-Cyclin B 26 nM (IC 50 ) |
CDK2/cyclinE 3 nM (IC 50 ) |
cdk2/cyclin A 4 nM (IC 50 ) |
CDK4/cyclin D 216 nM (IC 50 ) |
Cdk5/p25 10 nM (IC 50 ) |
CDK7/cyclin H 200 nM (IC 50 ) |
CDK9/cycT 13 nM (IC 50 ) |
PKC
|
CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC 50 of 84 nM. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP.
CGP-60474 (10?mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model.
| Animal Model: | C57Bl/6 mice (LPS endotoxemia model) |
| Dosage: | 10?mg/kg |
| Administration: | I.p. |
| Result: | Had a higher survival rate. |