16578-60-2
中文名稱(chēng)
[3-(hydroxymethyl)-2-nitrophenyl]methanol
英文名稱(chēng)
[3-(hydroxymethyl)-2-nitrophenyl]methanol
CAS
16578-60-2
分子式
C8H9NO4
分子量
183.16
MOL 文件
16578-60-2.mol
更新日期
2025/04/04 08:01:54
16578-60-2 結(jié)構(gòu)式
基本信息
中文別名
2-硝基-1,3-苯二甲醇1,3-二(羥甲基)-2-硝基苯
英文別名
1289461,3-Benzenedimethanol, 2-nitro-
1,3-di(hydroxymethyl)-2-nitrobenzene
[3-(hydroxymethyl)-2-nitrophenyl]methanol
物理化學(xué)性質(zhì)
熔點(diǎn)100-101 °C
沸點(diǎn)366.9±32.0 °C(Predicted)
密度1.420±0.06 g/cm3(Predicted)
溶解度DMSO (Slightly), Methanol (Slightly)
酸度系數(shù)(pKa)13.68±0.10(Predicted)
形態(tài)Solid
顏色Off White to Pale Yellow
應(yīng)用領(lǐng)域
用途一
2-Nitro-1,3-benzenedimethanol is an intermediate in the synthesis of 2,6-Dihydroxymethyl Rilpivirine (D446615), which is an analog of Rilpivirine (R509800) a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.