166335-18-8
166335-18-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16555 英文別名
PNU 103017Benzenesulfonamide, 4-cyano-N-[3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b]pyran-3-yl)methyl]phenyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)721.3±70.0 °C(Predicted)
密度1.39±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.50±1.00(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
PNU-103017 是一種 HIV 蛋白酶抑制劑。靶點(diǎn)
HIV protease
體內(nèi)研究
PNU-103017 is a selective HIV aspartyl protease inhibitor under evaluation as a potential oral treatment of Acquired Immunodeficiency Diseases. PNU-103017 is a racemic mixture of two enantiomers, designated PNU-103264 (R-) and PNU-103265 (S-). The C max (P≤0.0349), C min (P≤0.0168), and C av (P≤0.0118) are significantly higher for the (R)- than the (S)-enantiomer, showing enantioselective pharmacokinetics of PNU-103017 in the dog.